Elastase 3B Antibody [ELTS3B-2]
Product Specifications
Background
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six genes which encode the structurally similar proteins: Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, 3B has little elastolytic activity. Like most of the human elastases, 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. It may also function in the intestinal transport and metabolism of cholesterol. Elastases 3A/B have been referred to as Protease E and as Elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
NCBI Gene ID
23436
Swiss Prot
P08861
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
A partial recombinant protein (aa 82-238) was used as the immunogen for the Elastase 3B antibody.
Clonality
Monoclonal
Clone
ELTS3B-2
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
Protein G
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1
Applications Notes
1. FFPE staining requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min.
Symbol
CELA3B
NCBI Official Name
Chymotrypsin-like elastase family member 3B
NCBI Organism
Homo sapiens
Other Product Names
Chymotrypsin-like elastase family member 3B, Elastase IIIB, Elastase-3B, Protease E, CELA3B, ELA3B
Tested Applications
IHC-P, IF, ELISA
Physical Properties
Liquid
Curated Selection
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