NKX2.2 Antibody [NK2TF-1]
Product Specifications
Background
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. antibody to NKX2.2 detects a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
NCBI Gene ID
4821
Swiss Prot
O95096
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant human protein was used as the immunogen for this antibody.
Clonality
Monoclonal
Clone
NK2TF-1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=34-023
Fragment
IgG2b, kappa
Applications Notes
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Symbol
NKX2-2
NCBI Official Name
NK2 homeobox 2
NCBI Organism
Homo sapiens
Other Product Names
NKX2-2 Antibody: NKX2B, NKX2.2, NKX2B, Homeobox protein NK-2 homolog B
Tested Applications
IHC, IF
Physical Properties
Liquid
Curated Selection
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