GRP94 Antibody [SRPR90b]
Product Specifications
Background
Heat shock protein 90kDa beta member 1, known also as endoplasmin, gp96, grp94 and ERp99, is an HSP90 paralogue that is found in the endoplasmic reticulum. It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins. It has been implicated as an essential immune chaperone to regulate both innate and adaptive immunity. [Wiki]
NCBI Gene ID
7184
Swiss Prot
P14625
Host
Rat
Reactivity
Human
Immunogen
Recombinant full-length human HSP90B1 protein was used as the immunogen for the GRP94 antibody.
Clonality
Monoclonal
Clone
SRPR90b
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=34-004
Fragment
IgG2a, kappa
Applications Notes
1. FFPE testing requires sections to be boiled in pH6 10mM citrate buffer for 10-20 minutes, followed by cooling at RT for 20 minutes, prior to staining.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Symbol
HSP90B1
NCBI Official Name
Heat shock protein 90kDa beta (Grp94), member 1
NCBI Organism
Homo sapiens
Other Product Names
Endoplasmin, 94 kDa glucose-regulated protein, GRP-94, Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1, gp96 homolog, HSP90B1, GRP94, TRA1
Tested Applications
WB, IF, IHC-P
Physical Properties
Liquid
Curated Selection
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