TAG-72 Antibody [TAGP-4]
Product Specifications
Background
This antibody recognizes an oncofetal antigen of 220kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80% sensitivity and 93% specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution. This antibody may be useful in the differentiation of non-small cell carcinomas from small cell carcinomas of the lung. The combined use of TAG-72 antibody with a GCDFP-15 antibody is valuable in the diagnosis of apocrine carcinoma.
NCBI Gene ID
182875
Swiss Prot
Q9XVS1
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human TAG-72 protein was used as the immunogen for this antibody.
Clonality
Monoclonal
Clone
TAGP-4
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Applications Notes
1. No pretreatment is required for staining of formalin-fixed, paraffin-embedded tissues.
Symbol
Tag-72
NCBI Official Name
MRNA cap guanine-N7 methyltransferase
NCBI Organism
Caenorhabditis elegans
Tested Applications
Flow, IHC, IF
Physical Properties
Liquid
Curated Selection
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