Retinoblastoma / Rb Antibody [RB1/1754]
Product Specifications
Background
Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It reacts with the hyper-phosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.
NCBI Gene ID
5925
Swiss Prot
P06400
Host
Mouse
Reactivity
Human, Mouse
Immunogen
A human recombinant protein was used as the immunogen for this Rb antibody.
Clonality
Monoclonal
Clone
RB1/1754
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Symbol
RB1
NCBI Official Name
Retinoblastoma 1
NCBI Organism
Homo sapiens
Other Product Names
Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1
Tested Applications
WB, IP, IHC-P
Physical Properties
Liquid
Curated Selection
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