Plakophilin 1 Antibody [10B2]
Product Specifications
Background
Recognizes a protein of 75kDa, identified as Plakophilin 1 (PKP1) . Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. PKP1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress) . PKP2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart.
NCBI Gene ID
5317
Swiss Prot
Q13835
Host
Mouse
Reactivity
Human, Mouse
Immunogen
A N-terminal human recombinant protein fragment was used as the immunogen for the Plakophilin 1 antibody. Its epitope maps to between amino acids 1-27 of human PKP1.
Clonality
Monoclonal
Clone
10B2
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Symbol
PKP1
NCBI Official Name
Plakophilin 1
NCBI Organism
Homo sapiens
Tested Applications
WB, IF
Physical Properties
Liquid
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