HCG Receptor / LH Receptor Antibody [LHCGR/1417]

Product Specifications

Background

Recognizes a protein of 78-85kDa, which is identified as the receptor for Luteinizing hormone / Choriogonadotropin (LHR/CGR) . Luteinizing hormone plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Choriogonadotropin production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone / choriogonadotropin receptor (LHCGR) as a seven transmembrane, G protein-coupled receptor glycoprotein. LHCGR influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of LHCGR on breast carcinoma correlates in part to the degree of tumor differentiation. LHCGR -positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women.

NCBI Gene ID

3973

Swiss Prot

P22888

Host

Mouse

Reactivity

Human

Immunogen

A partial recombinant protein from the N-terminal region of human Luteinizing hormone / Choriogonadotropin receptor was used as the immunogen for the LHR antibody.

Clonality

Monoclonal

Clone

LHCGR/1417

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

Protein G affinity chromatography

Concentration

0.2 mg/mL

Buffer

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

Fragment

IgG1, kappa

Symbol

LHCGR

NCBI Official Name

Luteinizing hormone/choriogonadotropin receptor

NCBI Organism

Homo sapiens

Other Product Names

LHCGR, luteinizing hormone/choriogonadotropin receptor, LCGR, LGR2, LHR, hLHR, luteinizing hormone receptor, lutropin/choriogonadotropin receptor, LH receptor, CG receptor, LHRHR