Filaggrin Antibody [FLG/1562]
Product Specifications
Background
Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
NCBI Gene ID
2312
Swiss Prot
P20930
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 998-1104 of human FLG were used as the immunogen for this Filaggrin antibody.
Clonality
Monoclonal
Clone
FLG/1562
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Symbol
FLI1
NCBI Official Name
Friend leukemia virus integration 1
NCBI Organism
Homo sapiens
Other Product Names
FLI1 Antibody : ATOD2, Filaggrin
Tested Applications
WB, Flow, IHC, IF
Physical Properties
Liquid
Curated Selection
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