FSH Receptor Antibody [FSHR/1400]
Product Specifications
Background
Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its alpha and beta subunits. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, the beta subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG) . In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.
NCBI Gene ID
2492
Swiss Prot
P23945
Host
Mouse
Reactivity
Human
Immunogen
A human recombinant protein was used as the immunogen for this FSHR antibody.
Clonality
Monoclonal
Clone
FSHR/1400
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=33-686
Fragment
IgG1, kappa
Symbol
FSHR
NCBI Official Name
Follicle stimulating hormone receptor
NCBI Organism
Homo sapiens
Other Product Names
FSHR, Follitropin receptor, FSHRO, Ovarian dysgenesis 1, FSH receptor, FSH-R, LGR1, ODG1
Tested Applications
Flow, IHC, IF
Physical Properties
Liquid
Curated Selection
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