Kappa Light Chain Antibody [KLC1278]
Product Specifications
Background
This mAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
NCBI Gene ID
3514
Swiss Prot
P01601, P01834
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human Ig kappa chain was used as the immunogen for this Kappa Light Chain antibody.
Clonality
Monoclonal
Clone
KLC1278
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Symbol
IGKC
NCBI Official Name
Immunoglobulin kappa constant
NCBI Organism
Homo sapiens
Tested Applications
WB, Flow, IHC-P
Physical Properties
Liquid
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