FOXA1 Antibody [FOXA1/1512]
Product Specifications
Background
FOXA1 in breast cancer is highly correlated with ERalpha+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 acts as a pioneer factor for ERa in ERalpha+ breast cancer, and its expression might identify ERalpha+ cancers that undergo rapid reprogramming of ERa signaling that is associated with poor outcomes and treatment resistance. Conversely, in ERalpha− breast cancer FOXA1 is highly correlated with low-grade morphology and improved disease free survival. FOXA1 is a downstream target of GATA3 in the mammary gland. Expression in ERalpha− cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment. [Wiki]
NCBI Gene ID
3169
Swiss Prot
P55317
Host
Mouse
Reactivity
Human
Immunogen
A human partial recombinant protein corresponding to amino acids 372-472 was used as the immunogen for this FOXA1 antibody.
Clonality
Monoclonal
Clone
FOXA1/1512
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Specificity
Does not react with rat
Symbol
FOXA1
NCBI Official Name
Forkhead box A1
NCBI Organism
Homo sapiens
Other Product Names
FOXA1 Antibody: HNF3A, TCF3A, HNF3A, Hepatocyte nuclear factor 3-alpha, Forkhead box protein A1, HNF-3-alpha
Tested Applications
Flow, IHC, IF, WB
Physical Properties
Liquid
Curated Selection
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