Integrin beta 3 Antibody [ITGB3/1713]
Product Specifications
Background
Reacts with human Integrin beta 3, also called CD61. It associates with the alphaV-chain (CD51) to form vitronectin receptor, or with the alphaIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61) . The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
NCBI Gene ID
3690
Swiss Prot
P05106
Host
Mouse
Reactivity
Human
Immunogen
Human recombinant protein used as the immunogen for the Integrin beta 3 antibody.
Clonality
Monoclonal
Clone
ITGB3/1713
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Purification
Protein G affinity
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=33-635
Fragment
IgG1, kappa
Symbol
ITGB3
NCBI Official Name
Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
NCBI Organism
Homo sapiens
Other Product Names
Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A
Tested Applications
Flow, IF, IHC-P, IHC-Fr
Physical Properties
Liquid
Curated Selection
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