Beta Catenin Antibody [5H10]
Product Specifications
Background
Beta Catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo. Beta catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to gamma-Catenin, also known as plakoglobin. Beta-Catenin is widely expressed in many tissues. In cardiac muscle, it localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocyte. [Wiki]
NCBI Gene ID
1499
Swiss Prot
P35222
Host
Mouse
Reactivity
Human, Mouse, Chicken
Immunogen
A C-terminal 100 amino acid segment from chicken beta-Catenin was used as the immunogen for the Beta Catenin antibody.
Clonality
Monoclonal
Clone
5H10
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Symbol
CTNNB1
NCBI Official Name
Catenin (cadherin-associated protein), beta 1, 88kDa
NCBI Organism
Homo sapiens
Other Product Names
Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
Tested Applications
IHC-P, Flow, IF, WB
Physical Properties
Liquid
Curated Selection
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