Alpha Catenin Antibody [1G5]
Product Specifications
Background
Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-Catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-Catenin forms a heterodimer with beta-Catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-Catenin also regulates the beta-Catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer.
NCBI Gene ID
1495
Swiss Prot
P35221
Host
Mouse
Reactivity
Human
Immunogen
A human fusion protein was used as the immunogen for the Alpha Catenin antibody.
Clonality
Monoclonal
Clone
1G5
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Symbol
CTNNA1
NCBI Official Name
Catenin (cadherin-associated protein), alpha 1, 102kDa
NCBI Organism
Homo sapiens
Other Product Names
Catenin alpha-1, Alpha E-catenin, Cadherin-associated protein, Renal carcinoma antigen NY-REN-13, CTNNA1
Tested Applications
Flow, IF, WB
Physical Properties
Liquid
Frequently Asked Questions
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