Cdc2 Antibody [CDK1/873]

Product Specifications

Background

Recognizes a 34kDa protein, which is identified as cyclin dependent kinase 1 (cdk1) or p34cdc2 protein kinase. Cdc2 plays a crucial role during cell division and is most active during mitosis. It is predominantly localized in the nucleus. It is a serine/threonine kinase, which is activated by cyclin, presumably by de-phosphorylation of tyrosine residues. Activated Cdc2 performs specific functions during mitosis, including nuclear envelope breakdown and chromosome condensation.

NCBI Gene ID

983

Swiss Prot

P06493

Host

Mouse

Reactivity

Human, Monkey, Bovine, Mink

Immunogen

Recombinant human protein was used as the immunogen for the Cdc2 antibody.

Clonality

Monoclonal

Clone

CDK1/873

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Neuroscience

Purification

Protein G affinity chromatography

Concentration

0.2 mg/mL

Buffer

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

Fragment

IgG2a, kappa

Specificity

Does not react with Mouse, Rat, Xenopus, Drosophila, S. pombe, S. cerevisiae

Applications Notes

1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.

Symbol

CDK1

NCBI Official Name

Cyclin-dependent kinase 1

NCBI Organism

Homo sapiens

Other Product Names

Cyclin-dependent kinase 1, CDK1, Cell division control protein 2 homolog, Cell division protein kinase 1, p34 protein kinase, CDK1, CDC2, CDC28A, CDKN1, P34CDC2