TGFa Antibody [TG86]
Product Specifications
Background
This antibody reacts with the TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. The staining with this mAb is completely blocked by the peptide used for raising this antibody. TGFa is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
NCBI Gene ID
7039
Swiss Prot
P01135
Host
Mouse
Reactivity
Human, Rabbit, Zebrafish
Immunogen
Amino acids 34-43 (PPVAAAVVSH) from the human protein were used as the immunogen for the TGFa antibody.
Clonality
Monoclonal
Clone
TG86
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies, Antibody Pairs
Field of Research
Growth Factors
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Applications Notes
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Symbol
TGFA
NCBI Official Name
Transforming growth factor, alpha
NCBI Organism
Homo sapiens
Other Product Names
TFGAProtransforming growth factor alpha, EGF-like TGF, TGF-alpha
Tested Applications
Flow, IF, IHC-P
Physical Properties
Liquid
Curated Selection
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