HLA-DR Antibody [169-1B5.2]
Product Specifications
Background
This antibody detects a monomorphic general framework determinant of HLA-DR Class II antigen. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
NCBI Gene ID
3122
Swiss Prot
P01903
Host
Mouse
Reactivity
Human, Bovine, Cat
Immunogen
Human peripheral blood leukocytes were used as the immunogen for the HLA-DR antibody.
Clonality
Monoclonal
Clone
169-1B5.2
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG2b, kappa
Symbol
HLA-DRA
NCBI Official Name
Major histocompatibility complex, class II, DR alpha
NCBI Organism
Homo sapiens
Other Product Names
HLA class II histocompatibility antigen, DR alpha chain, MHC class II antigen DRA, HLA-DRA, HLA-DRA1
Tested Applications
WB, Flow, IF
Physical Properties
Liquid
Curated Selection
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