Blood Group Antigen H Type 2 Antibody [19-OLE]
Product Specifications
Background
Recognizes the blood group H type 2 antigens, trisaccharide Fuc (a1-2) Gal (b1-4) GlcNAc (b1) of human origin. This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. It is expressed on endothelial cells, epithelial cells and granulocytes. Increased expression of this antigen has been observed on some tumor tissues such as gastric carcinomas, urothelial carcinomas, and colon carcinomas.
NCBI Gene ID
28
Swiss Prot
P16442
Host
Mouse
Reactivity
Human
Immunogen
Mucinous colonic adenocarcinoma was used as the immunogen for the ABO antibody.
Clonality
Monoclonal
Clone
19-OLE
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
PEG precipitation
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=33-374
Fragment
IgM, kappa
Applications Notes
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min
Symbol
ABO
NCBI Official Name
Histo-blood group ABO system transferase
NCBI Organism
Homo sapiens
Other Product Names
Histo-blood group ABO system transferase, Fucosylglycoprotein 3-alpha-galactosyltransferase, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Histo-blood group A transferase, A transferase, Histo-blood group B transferase, B transferase, NAGAT, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form, ABO
Tested Applications
IF, IHC-P
Physical Properties
Liquid
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