CD16 Antibody [HuNK2]
Product Specifications
Background
Recognizes a protein of 50-65kDa, identified as CD16 (Workshop IV; Code N39) (also known low affinity Fc receptor III for IgG (FcRIII) or Leu 11) . CD16 exists as a polypepetide-anchored from (FCRIIIA or CD16A) on human natural killer (NK) cells and monocytes/ macrophages and as a glycosylphosphatidylinositol (GPI) -anchored form (FcRIIIB or CD16B) on neutrophils. CD16B is polymorphic and the two alleles are termed NA1 and NA2.3 CD16 plays a role in signal transduction, NK cell activation and antibody-dependent cellular cytotoxicity. This mAb has been showed to inhibit the binding of immune complex to NK cells, inhibit cytotoxicity of NK cells, and induce calcium fluxes in NK cells and neutrophils.
NCBI Gene ID
2214
Swiss Prot
P08637
Host
Mouse
Reactivity
Human
Immunogen
Human peripheral blood lymphocytes from a NK-leukemia patient were used as the immunogen for the CD16 antibody.
Clonality
Monoclonal
Clone
HuNK2
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG2a, kappa
Symbol
FCGR3A
NCBI Official Name
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
NCBI Organism
Homo sapiens
Other Product Names
Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Tested Applications
WB, Functional Assays, Flow, IF
Physical Properties
Liquid
Frequently Asked Questions
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