HCG-beta Antibody [HCGb/211]
Product Specifications
Background
This antibody reacts with a protein of 22kDa, identified as beta subunit of HCG. It does not cross react with the alpha subunit. HCG is a glycoprotein which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and beta subunits. The alpha subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH) . HCG-beta antibody detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate antibody positivity in 90% and 60% of cases respectively; 20% of lung squamous cell carcinomas are positive. HCG expression by non-trophoblastic tumors may indicate aggressive behavior.
NCBI Gene ID
1082
Swiss Prot
Q6NT52
Host
Mouse
Reactivity
Human
Immunogen
Purified HCG-beta protein was used as the immunogen for this antibody.
Clonality
Monoclonal
Clone
HCGb/211
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Applications Notes
1. Clone HCGb/211 (recommended capture) will pair with clones HCGb/459 and HCGb/54 (recommended detect) by ELISA. HCGb/459HCGb/54
Symbol
CGB
NCBI Official Name
Chorionic gonadotropin, beta polypeptide
NCBI Organism
Homo sapiens
Other Product Names
CGB, CGB3, CG-beta, Choriogonadotropin beta chain, HCGB, hCG Beta
Tested Applications
WB, IHC-Fr, ELISA
Physical Properties
Liquid
Curated Selection
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