Lambda Light Chain Antibody [ICO-106]
Product Specifications
Background
This antibody is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. In general the ratio of Kappa to Lambda is 3:1. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
NCBI Gene ID
3535
Swiss Prot
P01701; P01842
Host
Mouse
Reactivity
Human
Immunogen
Purified human Ig was used as the immunogen for this Lambda light chain antibody.
Clonality
Monoclonal
Clone
ICO-106
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=33-152
Fragment
IgG1, kappa
Applications Notes
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
Symbol
IGL
NCBI Official Name
Immunoglobulin lambda locus
NCBI Organism
Homo sapiens
Tested Applications
WB, Flow, IHC
Physical Properties
Liquid
Curated Selection
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