Ku70 + Ku80 Antibody [KU729]

Product Specifications

Background

This antibody recognizes a dimer of two proteins of 70kDa (Ku70) and ~80kDa (Ku80), identified as two subunits of Ku. Antbody KU729 recognizes a conformational epitope of the Ku70 + Ku80 dimer, which is destroyed during Western blotting. The Ku70 + Ku80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.

NCBI Gene ID

2547

Swiss Prot

Q6FG89

Host

Mouse

Reactivity

Human, Primate

Immunogen

Nuclear extract of human HL-60 cells was used as the immunogen for this Ku70 + Ku80 antibody.

Clonality

Monoclonal

Clone

KU729

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

Protein G purified monoclonal antibody

Concentration

0.2 mg/mL

Buffer

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

Fragment

IgG1, kappa

Specificity

Does not react with mouse, rat, chicken

Symbol

XRCC6

NCBI Official Name

X-ray repair complementing defective repair in Chinese hamster cells 6

NCBI Organism

Homo sapiens

Other Product Names

X-ray repair cross-complementing protein 6, 364-, 4299-, 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, Lupus Ku autoantigen protein p70, Ku70, Thyroid-lupus autoantigen, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 6, XRCC6, G22P1

Tested Applications

ICC, Flow, IF

Physical Properties

Liquid

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