Fibronectin Antibody [TV-1]
Product Specifications
Background
This antibody reacts with the cellular as well as plasma form of fibronectin. Reportedly, after iv administration, this antibody localizes to tumor vessels where it binds to the underlying basement. The Fibronectin epitope recognized by this antibody is not accessible in normal tissues to the circulating antibody indicating that it can be used to specifically target tumor vessels in vivo. Clone TV-1 fibronectin antibody is reportedly useful for delivering vasoactive agents to tumors to induce increased vascular permeability or blood flow prior to treatment with chemotherapeutic drugs or antibodies.
NCBI Gene ID
2335
Swiss Prot
P02751
Host
Mouse
Reactivity
Human, Pig, Mouse, Rat
Immunogen
A T-cell lymphoma biopsy was used as the immunogen for this fibronectin antibody.
Clonality
Monoclonal
Clone
TV-1
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=33-136
Fragment
IgG1, kappa
Applications Notes
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
Symbol
FN1
NCBI Official Name
Fibronectin 1
NCBI Organism
Homo sapiens
Other Product Names
FN1, CIG, DKFZp686F10164, DKFZp686H0342, DKFZp686I1370, DKFZp686O13149, FINC, FN, LETS, MSF, FNZ, ED-B, GFND, GFND2
Tested Applications
Flow, IHC, IF
Physical Properties
Liquid
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