HER2 Antibody [HRB2/282]
Product Specifications
Background
This antibody recognizes a protein of 185kDa, which is identified as HER2 / ErbB2. Its epitope is localized in the extracellular domain. HER2 is a member of the EGFR family. This antibody is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. HER2 / ErbB2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.
NCBI Gene ID
2064
Swiss Prot
P04626
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human HER2 protein was used as the immunogen for this antibody. (1)
Clonality
Monoclonal
Clone
HRB2/282
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Applications Notes
1. This HER2 antibody binds to the extracellular/cell surface region of the protein.
Symbol
ERBB2
NCBI Official Name
Erb-b2 receptor tyrosine kinase 2
NCBI Organism
Homo sapiens
Other Product Names
ErbB-2 Antibody: NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neu, MLN19, NEU, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein
Tested Applications
Flow, IF
Physical Properties
Liquid
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