HER2 Antibody [HRB2/258]

Product Specifications

Background

This antibody recognizes a protein of 185kDa, which is identified as HER2 / ErbB2. Its epitope is localized in the extracellular domain. ErbB2 is a member of the EGFR family. This antibody is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. ErbB2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

NCBI Gene ID

2064

Swiss Prot

P04626

Host

Mouse

Reactivity

Human, Rat

Immunogen

Recombinant human protein was used as the immunogen for this ErbB2 antibody. (1)

Clonality

Monoclonal

Clone

HRB2/258

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

Protein G purified

Concentration

0.2 mg/mL

Buffer

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

Fragment

IgG2a, kappa

Applications Notes

1. This ErbB2 antibody binds to the extracellular/cell surface region of the protein.

Symbol

ERBB2

NCBI Official Name

Erb-b2 receptor tyrosine kinase 2

NCBI Organism

Homo sapiens

Other Product Names

ErbB-2 Antibody: NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neu, MLN19, NEU, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein