CD28 Antibody [C28/75]
Product Specifications
Background
This antibody recognizes a glycoprotein of 44-88kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
NCBI Gene ID
940
Swiss Prot
P10747
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human CD28 protein was used as the immunogen for this antibody.
Clonality
Monoclonal
Clone
C28/75
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG1, kappa
Applications Notes
1. Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 1mM EDTA Buffer, pH 8.5-9.5, for 10-20 min followed by cooling at RT for 20 minutes.
Symbol
CD28
NCBI Official Name
CD28 molecule
NCBI Organism
Homo sapiens
Other Product Names
T-cell-specific surface glycoprotein CD28, TP44, CD28, CD28
Tested Applications
Functional Assays, Flow, IP, IHC
Physical Properties
Liquid
Frequently Asked Questions
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