GBL Antibody
Product Specifications
Background
GBL (G protein beta subunit-like), also called MLST8 (MTOR associated protein, LST8 homolog), is a subunit of the mTOR signaling complexes mTORC1 and mTORC2, which help regulate cell growth and survival in response to growth factor (mTORC1 & 2) and nutrient (mTORC1) signaling. It is required for the phosphorylation of S6 kinase and the signal adaptor protein Insulin receptor substrate 1 and S473 phosphorylation of AKT. GBL is also a regulator of TNFa-induced NF-kB activity, with overexpression inhibiting and down-regulation enhancing NF-kB signaling (Kim et al, 2008) .
NCBI Gene ID
64223
Swiss Prot
Q9BVC4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant protein fragment from the internal region of human GBL was used as the immunogen for this antibody.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Protein A affinity chromatography
Concentration
0.5 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.
Fragment
IgG
Symbol
MLST8
NCBI Official Name
G protein beta subunit-like
NCBI Organism
Homo sapiens
Other Product Names
GBL Antibody: GBL, LST8, POP3, WAT1, GbetaL, GBL, Target of rapamycin complex subunit LST8, G protein beta subunit-like, TORC subunit LST8
Tested Applications
WB
Physical Properties
Liquid
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