ATG4B Antibody
Product Specifications
Background
Autophagy is the cellular mechanism of degradation and turnover of unnecessary or dysfunctional cellular components. The unneeded components are engulfed in vesicles called autophagosomes, where they are broken down and recycled. The ‘autophagy-related gene’ ATG4B is a regulator of autophagasome maturation. The microtubule-associated protein LC3-I is lipidated (called LC3-II in its lipidated state) and recruited to the autophagosomal membrane where it is of vital importance in the maturation of autophagosomes. ATG4B regulates LC3-II availability by modulating LC3-I lipidation.
NCBI Gene ID
23192
Swiss Prot
Q9Y4P1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A recombinant protein fragment from the C-terminal region of ATG4B was used as the immunogen for this antibody.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy
Purification
Protein A affinity chromatography
Concentration
0.5 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.
Fragment
IgG
Symbol
ATG4B
NCBI Official Name
Autophagy related 4B, cysteine peptidase
NCBI Organism
Homo sapiens
Other Product Names
Autophagy related 4B cysteine peptidase, APG4B, APG4-B, AUTL1
Tested Applications
WB
Physical Properties
Liquid
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