ATF6 Antibody [AF6229]

Product Specifications

Background

ER stress can cause the accumulation of unfolded proteins and lead to the activation of the UPR (unfolded proetin response) . Cells have developed an intracellular signaling pathway to deal with this stress, and Activating Transcription Factor 6 (ATF6) is a major transducer of the UPR. Upon activation, ATF6 seperates from GPR78 and is cleaved. The ~50 kD cytosolic portion of ATF6 translocates to the nucleus, transmitting the ER stress signal. In the nucleus, ATF6 activates the transcription of UPR-responsive genes by biniding to their ERSE (ER stress response element) region.

NCBI Gene ID

22926

Swiss Prot

P18850

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

A recombinant protein fragment from the N-terminal region of human ATF6 was used as the immunogen for this antibody.

Clonality

Monoclonal

Clone

AF6229

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction, Apoptosis

Purification

Protein G purified monoclonal antibody

Concentration

0.5 mg/mL

Buffer

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.

Fragment

IgG1, kappa

Symbol

ATF6

NCBI Official Name

Activating transcription factor 6

NCBI Organism

Homo sapiens

Other Product Names

ATF6 Antibody: ATF6A, Cyclic AMP-dependent transcription factor ATF-6 alpha, Activating transcription factor 6 alpha, cAMP-dependent transcription factor ATF-6 alpha