ATF6 Antibody [AF6229]
Product Specifications
Background
ER stress can cause the accumulation of unfolded proteins and lead to the activation of the UPR (unfolded proetin response) . Cells have developed an intracellular signaling pathway to deal with this stress, and Activating Transcription Factor 6 (ATF6) is a major transducer of the UPR. Upon activation, ATF6 seperates from GPR78 and is cleaved. The ~50 kD cytosolic portion of ATF6 translocates to the nucleus, transmitting the ER stress signal. In the nucleus, ATF6 activates the transcription of UPR-responsive genes by biniding to their ERSE (ER stress response element) region.
NCBI Gene ID
22926
Swiss Prot
P18850
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant protein fragment from the N-terminal region of human ATF6 was used as the immunogen for this antibody.
Clonality
Monoclonal
Clone
AF6229
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Apoptosis
Purification
Protein G purified monoclonal antibody
Concentration
0.5 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=33-034
Fragment
IgG1, kappa
Symbol
ATF6
NCBI Official Name
Activating transcription factor 6
NCBI Organism
Homo sapiens
Other Product Names
ATF6 Antibody: ATF6A, Cyclic AMP-dependent transcription factor ATF-6 alpha, Activating transcription factor 6 alpha, cAMP-dependent transcription factor ATF-6 alpha
Tested Applications
WB, IHC
Physical Properties
Liquid
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