ICAD Antibody
Product Specifications
Background
During apoptosis, toxic or useless cells are broken down for removal. DFF, or DNA fragmentation factor, is a heterodimeric protein which mediates DNA fragmentation and chromatin condensation during apoptosis. DFFB is the active DFF subunit but remains inactive while bound to DFFA, also call ICAD (Inhibitor of caspase-activated DNase) . Caspase-3 cleaves ICAD, which then disassociates from DFFB. The disassociation removes the inhibitory effects of ICAD, activating DFFB and beginning the DNA fragmentation process.
NCBI Gene ID
1676
Swiss Prot
O00273
Host
Rabbit
Reactivity
Mouse
Immunogen
A recombinant protein fragment from human ICAD was used as the immunogen for this antibody.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
Protein A affinity chromatography
Concentration
0.5 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.
Fragment
IgG
Symbol
DFFA
NCBI Official Name
DNA fragmentation factor, 45kDa, alpha polypeptide
NCBI Organism
Homo sapiens
Other Product Names
DFF45 Antibody: DFF1, ICAD, DFF-45, DFF1, DFF45, H13, DNA fragmentation factor subunit alpha, DNA fragmentation factor 45 kDa subunit
Tested Applications
WB
Physical Properties
Liquid
Frequently Asked Questions
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