Survivin Antibody
Product Specifications
Background
Survivin, also called BIRC5, is a protein encoded by the human BIRC5 gene. It is a member of the IAP (inhibitor of apoptosis family. Survivin binds to the active form of Caspase-3 and -7, effector or executioner caspases, preventing them from continuing the apoptosis-signaling cascade. Expression is regulated by p53, a regulator of apoptosis-control genes which interacts with the Survivin gene promoter region to repress its expression at the mRNA and protein level.
NCBI Gene ID
332
Swiss Prot
O15392
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant protein fragment from human Survivin was used as the immunogen for this antibody.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Purification
Protein A affinity chromatography
Concentration
0.5 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.
Fragment
IgG
Symbol
BIRC5
NCBI Official Name
Baculoviral IAP repeat-containing 5
NCBI Organism
Homo sapiens
Other Product Names
Survivin Antibody: API4, EPR-1, API4, IAP4, Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor 4
Tested Applications
WB
Physical Properties
Liquid
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