SIN1 Antibody

Product Specifications

Background

MTOR, or Mammalian target of rapamycin, a large protein kinase, is a regulator of cell growth and survival via its mTORC1 (mTOR + GBL + Raptor) and mTORC2 (mTOR + GBL + SIN1 + Rictor) complexes. SIN1 is an essential component of mTORC2, which activates Akt by phosphorylating Ser473. Phosphorylation of SIN1 at Thr86/398 causes its dissociation from the mTORC2 complex, inhibiting mTORC2s kinase activity.

NCBI Gene ID

79109

Swiss Prot

Q9BPZ7

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog

Immunogen

A recombinant protein fragment from the C-terminal region of human SIN1 was used as the immunogen for this antibody.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

Protein A purified antibody

Concentration

0.5 mg/mL

Buffer

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.

Fragment

IgG

Symbol

MAPKAP1

NCBI Official Name

Mitogen-activated protein kinase associated protein 1

NCBI Organism

Homo sapiens

Other Product Names

MAPKAP1 Antibody: MIP1, SIN1, JC310, SIN1b, SIN1g, MIP1, Target of rapamycin complex 2 subunit MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, TORC2 subunit MAPKAP1