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DENND1B Antibody

Product Specifications

Background

Clathrin (see MIM 118955) -mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024) . Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]) .

NCBI Gene ID

163486

Swiss Prot

Q6P3S1

Accession Number

Q6P3S1

Host

Rabbit

Reactivity

Human

Immunogen

This DENND1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human DENND1B.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=55-155

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Symbol

DENND1B

NCBI Official Name

DENN domain-containing protein 1B

NCBI Organism

Homo sapiens

Background Reference 01

Marat, A.L., et al. J. Biol. Chem. 285 (14) :10627-10637 (2010)

Background Reference 02

Sleiman, P.M., et al. N. Engl. J. Med. 362 (1) :36-44 (2010)

Background Reference 03

Venter, J.C., et al. Science 291 (5507) :1304-1351 (2001)

Other Product Names

DENN domain-containing protein 1B, Connecdenn 2, Protein FAM31B, DENND1B, C1orf218, FAM31B

Tested Applications

WB, IHC-P, Flow

Protein ID

74749089

Physical Properties

Liquid

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