TFAM Antibody

Product Specifications

Background

This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.

NCBI Gene ID

7019

Swiss Prot

Q00059

Accession Number

Q00059

Host

Rabbit

Reactivity

Human

Immunogen

This TFAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-246 amino acids from the C-terminal region of human TFAM.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

29 kDa

Fragment

Rabbit Ig

Symbol

TFAM

NCBI Official Name

Transcription factor A, mitochondrial

NCBI Organism

Homo sapiens

Background Reference 01

Wang, W., et al. Nucleic Acids Res. (2010) In press :

Background Reference 02

Corneveaux, J.J., et al. Hum. Mol. Genet. 19 (16) :3295-3301 (2010)

Background Reference 03

Akhmetov, I.I., et al. Fiziol Cheloveka 36 (2) :121-125 (2010)

Background Reference 04

Shulman, J.M., et al. PLoS ONE (6), E11244 (2010) :

Other Product Names

Transcription factor A, mitochondrial, mtTFA, Mitochondrial transcription factor 1, MtTF1, Transcription factor 6, TCF-6, Transcription factor 6-like 2, TFAM, TCF6, TCF6L2