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FBXW12 Antibody

Product Specifications

Background

Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]) .[supplied by OMIM].

NCBI Gene ID

285231

Swiss Prot

Q6X9E4

Accession Number

Q6X9E4

Host

Rabbit

Reactivity

Human

Immunogen

This FBXW12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-320 amino acids from the C-terminal region of human FBXW12.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

53 kDa

Fragment

Rabbit Ig

Symbol

FBXW12

NCBI Official Name

F-box/WD repeat-containing protein 12

NCBI Organism

Homo sapiens

Background Reference 01

Jin, J., et al. Genes Dev. 18 (21) :2573-2580 (2004)

Background Reference 02

Zeng, L., et al. Mol. Biol. Rep. 31 (1) :51-57 (2004)

Other Product Names

F-box/WD repeat-containing protein 12, F-box and WD-40 domain-containing protein 12, F-box only protein 35, FBXW12, FBW12, FBXO12, FBXO35

Tested Applications

WB, IHC-P, Flow

Protein ID

215273983

Physical Properties

Liquid

Frequently Asked Questions

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