CLDN22 Antibody
Product Specifications
Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand.
NCBI Gene ID
53842
Swiss Prot
Q8N7P3
Accession Number
Q8N7P3
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CLDN22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids from the Central region of human CLDN22.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
25 kDa
Fragment
Rabbit Ig
Symbol
CLDN22
NCBI Official Name
Claudin-22
NCBI Organism
Homo sapiens
Background Reference 01
Lal-Nag, M., et al. Genome Biol. 10 (8), 235 (2009) :
Background Reference 02
Krause, G., et al. Biochim. Biophys. Acta 1778 (3) :631-645 (2008)
Background Reference 03
Hillier, L.W., et al. Nature 434 (7034) :724-731 (2005)
Background Reference 04
Katoh, M., et al. Int. J. Mol. Med. 11 (6) :683-689 (2003)
Other Product Names
Claudin-22, CLDN22
Tested Applications
WB, Flow
Protein ID
62298548
Physical Properties
Liquid
Curated Selection
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