FBXO2 Antibody

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.

This FBXO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-271 amino acids from the C-terminal region of human FBXO2.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Eom, C.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 100 (17) :9803-9807 (2003) Ilyin, G.P., et al. Gene 296 (1-2), 11-20 (2002) Yoshida, Y., et al. Nature 418 (6896) :438-442 (2002) Winston, J.T., et al. Curr. Biol. 9 (20) :1180-1182 (1999) Cenciarelli, C., et al. Curr. Biol. 9 (20) :1177-1179 (1999)