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FUS Antibody

Product Specifications

Background

This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.

NCBI Gene ID

2521

Swiss Prot

P35637

Accession Number

P35637

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This FUS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-526 amino acids from the C-terminal region of human FUS.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=55-074

Calculated Molecular Weight

53 kDa

Fragment

Rabbit Ig

Symbol

FUS

NCBI Official Name

RNA-binding protein FUS

NCBI Organism

Homo sapiens

Background Reference 01

Kim, S.H., et al. J. Biol. Chem. 285 (44) :34097-34105 (2010)

Background Reference 02

Mackenzie, I.R., et al. Lancet Neurol 9 (10) :995-1007 (2010)

Background Reference 03

Yan, J., et al. Neurology 75 (9) :807-814 (2010)

Background Reference 04

Waibel, S., et al. Neurology 75 (9) :815-817 (2010)

Other Product Names

RNA-binding protein FUS, 75 kDa DNA-pairing protein, Oncogene FUS, Oncogene TLS, POMp75, Translocated in liposarcoma protein, FUS, TLS

Tested Applications

WB, IHC-P, IF, Flow

Protein ID

544357

Physical Properties

Liquid

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