CCL21 Antibody

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19) . [provided by RefSeq].

This CCL21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-52 amino acids from the Central region of human CCL21.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Rey-Gallardo, A., et al. Glycobiology 20 (9) :1139-1146 (2010) Cuesta-Mateos, C., et al. Exp. Hematol. 38 (9) :756-764 (2010) Sundqvist, J., et al. Fertil. Steril. (2010) In pressPlant, D., et al. Ann. Rheum. Dis. 69 (8) :1548-1553 (2010) Farragher, T.M., et al. Arthritis Care Res (Hoboken) 62 (5) :676-682 (2010)