ACOT11 Antibody

Product Specifications

Background

This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants.

NCBI Gene ID

26027

Swiss Prot

Q8WXI4

Accession Number

Q8WXI4

Host

Rabbit

Reactivity

Human

Immunogen

This ACOT11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-575 amino acids from the C-terminal region of human ACOT11.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

68 kDa

Fragment

Rabbit Ig

Symbol

ACOT11

NCBI Official Name

Acyl-coenzyme A thioesterase 11

NCBI Organism

Homo sapiens

Background Reference 01

Kirkby, B., et al. Prog. Lipid Res. 49 (4) :366-377 (2010)

Background Reference 02

Hunt, M.C., et al. J. Lipid Res. 46 (9) :2029-2032 (2005)

Background Reference 03

Adams, S.H., et al. Biochem. J. 360 (PT 1), 135-142 (2001) :

Other Product Names

Acyl-coenzyme A thioesterase 11, Acyl-CoA thioesterase 11, 312-, Acyl-CoA thioester hydrolase 11, Adipose-associated thioesterase, Brown fat-inducible thioesterase, BFIT, ACOT11, BFIT, KIAA0707, THEA