AMACR Antibody

Product Specifications

Background

This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R) - and (S) -stereoisomers. The conversion to the (S) -stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.

NCBI Gene ID

23600

Swiss Prot

Q9UHK6

Accession Number

Q9UHK6

Host

Rabbit

Reactivity

Human

Immunogen

This AMACR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-351 amino acids from the C-terminal region of human AMACR.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

42 kDa

Fragment

Rabbit Ig

Symbol

AMACR

NCBI Official Name

Alpha-methylacyl-CoA racemase

NCBI Organism

Homo sapiens

Background Reference 01

Murray, N.P., et al. Oncol. Rep. 24 (3) :687-692 (2010) Sonwalkar, S.A., et al. Histopathology 56 (7) :900-907 (2010) Lakis, S., et al. World J. Gastroenterol. 16 (20) :2476-2483 (2010) Chen, W., et al. Mol. Biol. Rep. 36 (3) :423-430 (2009) Mubiru, J.N., et al. Gene 327 (1) :89-98 (2004)