DOK2 Antibody
Product Specifications
Background
DOK2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK2 binds p120 (RasGAP) from CML cells.The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.
NCBI Gene ID
9046
Swiss Prot
O60496
Accession Number
NP_003965
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DOK2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store DOK2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=31-076
Calculated Molecular Weight
45 kDa
Applications Notes
DOK2 antibody can be used for detection of DOK2 by ELISA at 1:62500. DOK2 antibody can be used for detection of DOK2 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
DOK2
NCBI Official Name
Docking protein 2, 56kDa
NCBI Organism
Homo sapiens
Background Reference 01
Boulay, I., et al., (2005) J. Immunol. 175 (7), 4483-4489.
Other Product Names
DOK2, p56DOK, p56dok-2
Tested Applications
ELISA, WB
Protein ID
41406050
Physical Properties
Liquid
Curated Selection
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