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FADD Antibody

Product Specifications

Background

The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.

NCBI Gene ID

8772

Swiss Prot

Q13158

Accession Number

NP_003815

Host

Rabbit

Reactivity

Human

Immunogen

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human FADD.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Signal Transduction, Immunology, Apoptosis , Inflammasomes

Purification

Antibody is purified by peptide affinity chromatography method.

Positive Control

Cat. No. XBL-10426 - Fetal Thymus Tissue Lysate

Concentration

Batch dependent

Buffer

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store FADD antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=31-008

Calculated Molecular Weight

23 kDa

Applications Notes

FADD antibody can be used for detection of FADD by ELISA at 1:62500. FADD antibody can be used for detection of FADD by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Symbol

FADD

NCBI Official Name

Fas (TNFRSF6) -associated via death domain

NCBI Organism

Homo sapiens

Background Reference 01

Thomas, L.R., et al., (2004) J. Biol. Chem. 279 (31), 32780-32785.

Other Product Names

FADD, GIG3, MORT1

Tested Applications

ELISA, WB, IHC

Protein ID

4505229

Physical Properties

Liquid

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