FADD Antibody
Product Specifications
Background
The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.
NCBI Gene ID
8772
Swiss Prot
Q13158
Accession Number
NP_003815
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human FADD.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction, Immunology, Apoptosis , Inflammasomes
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10426 - Fetal Thymus Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store FADD antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
23 kDa
Applications Notes
FADD antibody can be used for detection of FADD by ELISA at 1:62500. FADD antibody can be used for detection of FADD by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
FADD
NCBI Official Name
Fas (TNFRSF6) -associated via death domain
NCBI Organism
Homo sapiens
Background Reference 01
Thomas, L.R., et al., (2004) J. Biol. Chem. 279 (31), 32780-32785.
Other Product Names
FADD, GIG3, MORT1
Tested Applications
ELISA, WB, IHC
Protein ID
4505229
Physical Properties
Liquid
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