PHB2 Antibody
Product Specifications
Background
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity) . It functions as an estrogen receptor (ER) -selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. PHB2 competes with NCOA1 for modulation of ER transcriptional activity. It probably involved in regulating mitochondrial respiration activity and in aging.
NCBI Gene ID
11331
Swiss Prot
Q99623
Accession Number
NP_009204
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PHB2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer, Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PHB2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=30-396
Calculated Molecular Weight
33 kDa
Applications Notes
PHB2 antibody can be used for detection of PHB2 by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PHB2
NCBI Official Name
Prohibitin 2
NCBI Organism
Homo sapiens
Background Reference 01
Ross, J.A., (2008) J. Biol. Chem. 283 (8), 4699-4713.
Other Product Names
PHB2, BAP, BCAP37, Bap37, MGC117268, PNAS-141, REA, p22
Tested Applications
WB
Protein ID
6005854
Physical Properties
Liquid
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