PSMC3IP Antibody
Product Specifications
Background
PSMC3IP plays an important role in meiotic recombination. It stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.
NCBI Gene ID
29893
Swiss Prot
Q9P2W1
Accession Number
NP_057640
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PSMC3IP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PSMC3IP antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=30-304
Calculated Molecular Weight
25 kDa
Applications Notes
PSMC3IP antibody can be used for detection of PSMC3IP by ELISA at 1:62500. PSMC3IP antibody can be used for detection of PSMC3IP by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PSMC3IP
NCBI Official Name
PSMC3 interacting protein
NCBI Organism
Homo sapiens
Background Reference 01
Enomoto, R., (2006) J. Biol. Chem. 281 (9), 5575-5581.
Other Product Names
PSMC3IP, GT198, HOP2, TBPIP, ODG3, HUMGT198A
Tested Applications
ELISA, WB
Protein ID
7706577
Physical Properties
Liquid
Curated Selection
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