ZMPSTE24 Antibody
Product Specifications
Background
ZMPSTE24 is a member of the peptidase M48A family. This protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in ZMPSTE24 gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.The protein encoded by this gene is a zinc metalloprotease similar to yeast Ste24p. It is an integral membrane protein belonging to peptidase family M48 and is found in the endoplasmic reticulum and possibly in the Golgi compartment. It is thought to be involved in the proteolytic processing of farnesylated proteins.
NCBI Gene ID
10269
Swiss Prot
O75844
Accession Number
NP_005848
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ZMPSTE24.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ZMPSTE24 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=30-216
Calculated Molecular Weight
55 kDa
Applications Notes
ZMPSTE24 antibody can be used for detection of ZMPSTE24 by ELISA at 1:312500. ZMPSTE24 antibody can be used for detection of ZMPSTE24 by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
ZMPSTE24
NCBI Official Name
Zinc metallopeptidase STE24
NCBI Organism
Homo sapiens
Background Reference 01
Moulson, C.L., (2005) J. Invest. Dermatol. 125 (5), 913-919.
Other Product Names
ZMPSTE24, FACE-1, FACE1, FLJ14968, STE24, Ste24p, HGPS, PRO1
Tested Applications
ELISA, WB
Protein ID
18379366
Physical Properties
Liquid
Curated Selection
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