ACVR2B Antibody

Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B is activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ACVR2B antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

ACVR2B antibody can be used for detection of ACVR2B by ELISA at 1:312500. ACVR2B antibody can be used for detection of ACVR2B by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.