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ALAS2 Antibody

Product Specifications

Background

ALAS2 specifies an erythroid-specific mitochondrially located enzyme. The protein catalyzes the first step in the heme biosynthetic pathway. Defects in its gene cause X-linked pyridoxine-responsive sideroblastic anemia.The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.

NCBI Gene ID

212

Swiss Prot

P22557

Accession Number

NP_001033058

Host

Rabbit

Reactivity

Human

Immunogen

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ALAS2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibody is purified by protein A chromatography method.

Positive Control

Cat. No. 1205 - Jurkat Cell Lysate

Concentration

Batch dependent

Buffer

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ALAS2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

Calculated Molecular Weight

57 kDa, 65 kDa, 61 kDa, 63 kDa

Applications Notes

ALAS2 antibody can be used for detection of ALAS2 by ELISA at 1:62500. ALAS2 antibody can be used for detection of ALAS2 by western blot at 5.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Symbol

ALAS2

NCBI Official Name

Aminolevulinate, delta-, synthase 2

NCBI Organism

Homo sapiens

Background Reference 01

Astner, I., (2005) EMBO J. 24 (18), 3166-3177.

Other Product Names

ALAS2, ANH1, ASB, PRO2399, XLSA, ALASE, XLDPP, XLEPP, ALAS-E

Tested Applications

ELISA, WB, IHC

Protein ID

189217859

Physical Properties

Liquid

Frequently Asked Questions

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