AGER Antibody
Product Specifications
Background
AGER mediates interactions of advanced glycosylation end products (AGE) . These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. It is receptor for amyloid beta peptide.This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms.
NCBI Gene ID
177
Swiss Prot
A2BFI7
Accession Number
NP_751947
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human AGER.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Cancer, Signal Transduction, Immunology
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store AGER antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=29-611
Calculated Molecular Weight
38 kDa
Applications Notes
AGER antibody can be used for detection of AGER by ELISA at 1:62500. AGER antibody can be used for detection of AGER by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
AGER
NCBI Official Name
Advanced glycosylation end product-specific receptor
NCBI Organism
Homo sapiens
Background Reference 01
Scherer, S.W., (2006) Thromb. Haemost. 95 (2), 320-328.
Other Product Names
AGER, MGC22357, RAGE
Tested Applications
ELISA, WB, IHC
Protein ID
26787962
Physical Properties
Liquid
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