FIP1L1 Antibody
Product Specifications
Background
FIP1L1 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly (A) polymerase and other factors to bring about cleavage and poly (A) addition. FIP1L1 contributes to poly (A) site recognition and stimulates poly (A) addition. It binds to U-rich RNA sequence elements surrounding the poly (A) site. FIP1L1 may act to tether poly (A) polymerase to the CPSF complex.
NCBI Gene ID
81608
Swiss Prot
Q6UN15
Accession Number
NP_112179
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human FIP1L1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store FIP1L1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
65 kDa
Applications Notes
FIP1L1 antibody can be used for detection of FIP1L1 by ELISA at 1:62500. FIP1L1 antibody can be used for detection of FIP1L1 by western blot at 0.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
FIP1L1
NCBI Official Name
Factor interacting with PAPOLA and CPSF1
NCBI Organism
Homo sapiens
Background Reference 01
Zhao, X., (2005) J. Virol. 79 (7), 4270-4288.
Other Product Names
FIP1L1, DKFZp586K0717, FLJ33619, Rhe, FIP1, hFip1
Tested Applications
ELISA, WB
Protein ID
40254978
Physical Properties
Liquid
Curated Selection
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